Endocrine Abstracts

Introduction: The congenital cystic neck masses underlie various diagnosis including tymic cysts. Even they are an embryological defects, the adult onset might be seen. The aetiology is not clearly established. The malignant behaviour or infections are correlated to the cysts. Aim: we present a female case with a complicated history of cysts.Case report: 42-year old female is known with the following medical history. Seven years ago she was operated for ...

Introduction: The fat mass (FM) is assessed by DXA, magnetic resonance, etc. One of the most accessible methods for current practice is bioimpedance.Aim: We analyzed FM based on bioimpedance and fragility fracture risk.Material and method: This is a transversal study in women, admitted at C.I.Parhon National Institute of Endocrinology, Bucharest, Romania. The inclusion criteria were women in menopause. The exclusion criteria were p...

Introduction: Patients with untreated acromegaly have a reduced survival, mostly due to vascular disease. Recent studies claim an improvement of survival in the last years.Aims: To assess mortality ratio and to identify prognostic factors associated with reduced survival in acromegaly.Methods: Three hundred and twenty-seven patients (207 F/110 M, mean age 48.1±0.7 years, (range 18–81.42)) with acromegaly admitted in a sin...

Background: PA is a frequent cause (5–13%) of secondary hypertension (HT), yet diagnostic work-up of PA remains challenging.Aim: To describe the characteristics of a series of hypertensive patients diagnosed with PA compared to those with negative biochemical screening (aldosterone-to-renin ratio/ARR)Methods: Clinical, hormonal and imaging evaluation.Results: We have screened for PA 34 patients diagnose...

Introduction: We have recently described a novel AIP mutation c.940C>T, p.R314W, in a young sporadic acromegaly patient.Aim: To present a new case of AIP p.R314W mutation and screening results of a Romanian control group for p.R314W.Patients and methods: One sporadic acromegaly patient, investigated by sequencing screening of all six AIP exons, following informed consent, as part of a sporadic pituitary adenoma cohort. 110 cont...

Background: Craniopharyngioma is a rare, mostly benign tumor of the central nervous system, generally associated with important morbidity.Aim: To study the clinical characteristics and treatment outcome in adult patients.Methods:: Adult patients diagnosed with craniopharyngioma between 1980 and 2012, followed-up in the Pituitary and Neuroendocrine Department of the ‘C.I.Parhon’ National Institute of Endocrinology in Bucha...

Introduction: The management of a thyroid nodule in a patient who is newly diagnosed with an active cancer depends not only of the thyroid disease its self but also of the prognosis of the second neoplasia.Aim: We present a case of a male who was admitted to an endocrinologist for a thyroid nodule evaluation.Case presentation: B.C., 66-year-old male patient, smoker from the last 17 years, was treated with thyamazol for hyperthyroid...

Introduction: Testosterone therapy in elderly is controversial, because of the effect on prostate. The old age itself is not a contraindication in the therapy of hypogonadism.Aim: We analyze the effect of 24 months of therapy with testosterone undecanoat depot (1000 mg/4 ml) (TUD) on the volume of the prostate (VP).Patients and method: The patients were 79 symptomatic hypogonadic men, with normal value of PSA (<4 g/l). The urol...

Introduction: Sorafenib, an orphan medication, is an oral protein kinase inhibitor, used in the treatment of hepatic, advanced renal and breast cancer, or metastatic iodine-refractary thyroid cancer. The drug also inhibits angiogenesis, and VEGF, having a dual effect on the tumor cells as well as on the tumor vasculature.Aim: We present a case with hyperthyroidism, as adverse effect of the therapy with sorafenib, but with no markers of thyroid autoimmuni...

Introduction: Pituitary adenomas (PAs) are rare in childhood and the transition period, can result from AIP/MEN1 mutations, are difficult to manage and severely impair quality-of-life.Aim: To describe the clinical and genetic characteristics of patients with PA onset before 21 years old.Patients and methods: Retrospective study (1980–2015). Clinical, imaging and hormonal data, AIP/MEN1 sequencing.<p class...